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    Publications | Abstracts

 Biswas B, Spitznagel E, Collier A, Gelman B, McArthur J, Morgello S, McCutchan JA, Clifford DB and the CHARTER Group.  (2014). Characterizing HIV medication adherence for virologic successes among individuals living with HIV/AIDS: Lessons from the CNS HIV Antiretroviral Therapy Effects Research. Journal of HIV/AIDS & Social Services, 13(1), 8-25. PMCID: PMC3963153  
Keltner JR, Fennema-Notestine C, Vaida F, Wang D, Franklin DR, Dworkin RH, Sanders C, McCutchan JA, Archibald SL, Miller DJ, Kesidis G, Cushman C, Kim SM, Abramson I, Taylor MJ, Theilmann RJ, Julaton MD, Notestine RJ, Corkran S, Cherner M, Duarte NA, Alexander T, Robinson-Papp J, Gelman BB, Simpson DM, Collier AC, Marra CM, Morgello S, Brown G, Grant I, Atkinson JH, Jernigan TL, Ellis RJ.  (2014). HIV-associated distal neuropathic pain is associated with smaller total cerebral cortical gray matter. Journal of Neurovirology, Epub. Feb. 19. PMID: 24549970  
Marquine MJ, Umlauf A, Rooney A, Fazeli P, Gouaux B, Woods SP, Letendre SL, Ellis RJ, Grant I, Moore DJ and the HNRP Group.  (2014). The Veterans Administration Cohort Study (VACS) Index is associated with concurrent risk for neurocognitive impairment. Journal of Acquired Immune Deficiency Syndromes, 65(2), 190-197. PMID: 24442225  PMCID: PMC3907119  
Bandaru VVR, Mielke MM, Sacktor N, McArthur JC, Grant I, Letendre S, Chang L, Wojna V, Pardo C, Calabresi P, Munsaka S, Haughey NJ.  (2013). A lipid storage-like disorder contributes to cognitive decline in HIV-infected subjects. Neurology, 81(17), 1492-1499. PMID: 24027056  PMCID: PMC3888167  
Morgan EE, Woods SP, Letendre SL, Franklin DR, Bloss C, Goate A, Heaton RK, Collier AC, Marra CM, Gelman BB, McArthur JC, Morgello S, Simpson DM, McCutchan JA, Ellis RJ, Abramson I, Gamst A, Fennema-Notestine C, Smith DM, Grant I, Vaida F, Clifford DB; The CNS HIV Antiretroviral Therapy Effects Research (CHARTER) Group.  (2013). Apolipoprotein E4 genotype does not increase risk of HIV-associated neurocognitive disorders. Journal of NeuroVirology, 19(2), 150-156. PMID: 23408335  PMCID: PMC3668779  
Sakamoto M, Marcotte TD, Umlauf A, Franklin D, Heaton RK, Ellis RJ, Letendre S, Alexander T, McCutchan JA, Morgan EE, Woods SP, Collier AC, Marra CM, Clifford DB, Gelman BB, McArthur JC, Morgello S, Simpson D, Grant I.  (2013). Concurrent classification accuracy of the HIV Dementia Scale for HIV-associated neurocognitive disorders in the CHARTER Cohort. Journal of Acquired Immune Deficiency Syndromes, 62(1), 36-42. PMID: 23111573  PMCID: PMC3529802  
Croteau D, Rossi SS, Best BM, Capparelli E, Ellis RJ, Clifford DB, Collier AC, Gelman BB, Marra CM, McArthur J, McCutchan JA, Morgello S, Simpson DM, Grant I, Letendre S.  (2013). Darunavir is predominantly unbound to protein in cerebrospinal fluid and concentrations exceed the wild-type HIV-1 median 90% inhibitory concentration. The Journal of Antimicrobial Chemotherapy, 68(3), 684-689. PMID: 23143899  PMCID: PMC3566670  
Burdo TH, Weiffenbach A, Woods SP, Letendre S, Ellis RJ, Williams KC.  (2013). Elevated SCD163 in plasma but not csf is a marker of neurocognitive impairment in HIV infection. AIDS (London, England), 27(9), 1387-1395. PMID: 23435298  PMCID: PMC3844286  
Nguyen A, Rossi S, Croteau D, Best BM, Clifford D, Collier AC, Gelman B, Marra C, McArthur J, McCutchan JA, Morgello S, Simpson D, Ellis RJ, Grant I, Capparelli E, Letendre S, on behalf of the CHARTER Group.  (2013). Etravirine in CSF is highly protein bound. The Journal of Antimicrobial Chemotherapy, 68(5), 1161-1168. PMID: 23335197  PMCID: PMC3625433  
 Fennema-Notestine C, Ellis RJ, Archibald SL, Jernigan TL, Letendre SL, Notestine R, Taylor MJ, Theilmann RJ, Julaton MD, Croteau D, Wolfson T, Heaton RK, Gamst AC, Franklin DR, Clifford DB, Collier AC, Gelman BB, Marra C, McArthur JC, McCutchan JA, Morgello S, Simpson DM, Grant I, for the CHARTER Group.  (2013). Increases in brain MR white matter abnormalities and subcortical gray matter are linked to CD4 recovery in HIV on antiretroviral therapy. Journal of NeuroVirology, 19(4), 393-401. PMID: 23838849  PMCID: PMC3776609  
Fennema-Notestine C, Ellis RJ, Archibald SL, Jernigan TL, Letendre SL, Notestine RJ, Taylor MJ, Theilmann RJ, Julaton MD, Croteau DJ, Wolfson T, Heaton RK, Gelman BB, Marra C, McArthur JC, McCutchan JA, Morgello S, Simpson DM, Grant I, for the CHARTER Group.  (2013). Increases in brain white matter abnormalities and subcortical gray matter are linked to CD4 recovery in HIV infection. Journal of NeuroVirology, 19(4), 393-401. PMID: 23838849  PMCID: PMC3776609  
Marra CM, Deutsch R, Collier AC, Morgello S, Letendre S, Clifford D, Gelman B, McArthur J, McCutchan JA, Simpson DM, Duarte NA, Heaton RK, Grant I.  (2013). Neurocognitive impairment in HIV-infected individuals with previous syphilis. International Journal of STD & AIDS, 24(5), 351-355. PMID: 23970701  
Andrade A, Deutsch R, Celano S, Duarte NA, Marcotte TD, Umlauf A, Atkinson JH, McCutchan JA, Franklin D, Alexander TJ, McArthur J, Marra C, Grant I, Collier AC.  (2013). Relationships among neurocognitive status, medication adherence measured by pharmacy refill records, and virologic suppression in HIV-infected persons. Journal of Acquired Immune Deficiency Syndromes, 62(3), 282-92. PMID: 23202813  PMCID: PMC3906725  
Kamat A, Misra V, Cassol E, Ancuta P, Yan Z, Li C, Morgello S, Gabuzda D.  (2012). A plasma biomarker signature of immune activation in HIV patients on antiretroviral therapy. PLoS One, 7(2), e30881. PMID: 22363505  PMCID: PMC3281899  
Perez-Valero I, Cysique L, Letendre S, Heaton R.  (2012). Comments to Garvey et al.: "Low rates of neurocognitive impairment are observed in neuro-asymptomatic HIV-infected subjects on effective antiretroviral therapy". HIV Clinical Trials, 13(5), 296-298. PMID: 23134631  
Blackstone K, Moore DJ, Franklin Dr, Clifford DB, Collier, AC, Marra CM, Gelman BB, McArthur JC, Morgello S, Simpson DM, Ellis RJ, Atkinson JH, Grant I, Heaton RK, for the CHARTER Group.  (2012). Defining neurocognitive impairment in HIV: Deficit scores versus clinical ratings. The Clinical Neuropsychologist, 26(6), 894-908. PMID: 22708483  PMCID: PMC3848322  
Blackstone K, Moore DJ, Heaton RK, Franklin DR, Woods SP, Clifford DB, Collier AC, Marra CM, Gelman BB, McArthur JC, Morgello S, Simpson DM, Rivera-Mindt M, Deutsch R, Ellis RJ, Hampton Atkinson J, Grant I, and the CHARTER Group.  (2012). Diagnosing symptomatic HIV-associated neurocognitive disorders: Self-report versus performance-based assessment of everyday functioning. Journal of the International Neuropsychological Society, 18(1), 79-88. PMID: 22114912  PMCID: PMC3882265  
Choi JY, Hightower GK, Wong JK, Heaton R, Woods S, Grant I, Marcotte TD, Ellis RJ, Letendre SL, Collier AC, Marra CM, Clifford DB, Gelman BB, McArthur JC, Morgello S, Simpson DM, McCutchan JA, Richman DD, Smith DM, and the CHARTER Group.  (2012). Genetic features of cerebrospinal fluid-derived Subtype B HIV-1 Tat. Journal of NeuroVirology, 18(2), 81-90. PMID: 22528397  PMCID: PMC2572198  
Keltner JR, Vaida F, Ellis RJ, Moeller-Bertram T, Fitzsimmons C, Duarte NA, Robinson-Papp J, Dworkin RH, Clifford DB, McArthur JC, Simpson DM, Collier AC, Marra CM, Atkinson JH, Grant I, and the CHARTER Group.  (2012). Health-related quality of life 'Well-Being' in HIV distal neuropathic pain is more strongly associated with depression severity than with pain intensity. Psychosomatics, 53(4), 380-386. PMID: 22748751  PMCID: PMC3389373  
Hightower GK, Wong JK, Letendre SL, Umlauf AA, Ellis RJ, Ignacio CC, Heaton RK, Collier AC, Marra CM, Clifford DB, Gelman BB, McArthur JC, Morgello S, Simpson DM, McCutchan JA, Grant I, Little SJ, Richman DD, Pond SLK, Smith DM, and the CHARTER Study Group.  (2012). Higher HIV-1 genetic diversity is associated with AIDS and neuropsychological impairment. Virology, 433(2), 498-505. PMID: 22999095  PMCID: PMC3466337  
Badiee J, Moore DJ, Atkinson JH, Vaida F, Gerard M, Duarte NA, Franklin D, Gouaux B, McCutchan JA, Heaton RK, McArthur J, Morgello S, Simpson D, Collier A, Marra CM, Gelman B, Clifford D, Grant I.  (2012). Lifetime suicidal ideation and attempt are common among HIV+ individuals. Journal of Affective Disorders, 136(3), 993-999. PMID: 21784531  PMCID: PMC3222733  
Best BM, Letendre SL, Koopmans P, Rossi SS, Clifford DB, Collier AC, Gelman BB, Marra CM, McArthur JC, McCutchan JA, Morgello S, Simpson DM, Capparelli EV, Ellis RJ, Grant I, and the CHARTER Study Group.  (2012). Low CSF concentrations of the nucleotide HIV reverse transcriptase inhibitor, Tenofovir. Journal of AIDS, 59(4), 376-381. PMID: 22217676  PMCID: PMC3299895  
Croteau D, Best BM, Letendre S, Rossi SS, Ellis RJ, Clifford DB, Collier AC, Gelman BB, McArthur JC, McCutchan JA, Morgello S, Grant I, and the CHARTER Group.  (2012). Lower than expected maraviroc concentrations in cerebrospinal fluid exceed the wild-type CCR5-tropic HIV-1 50% inhibitory concentration. AIDS, 26(7), 890-893. PMID: 22313954  PMCID: PMC3454507  
Holzinger ER, Hulgan T, Ellis RJ, Samuels DC, Ritchie MD, Haas DW, Kallianpur AR, Bloss CS, Clifford DB, Collier AC, Gelman BB, Marra CM, McArthur JC, McCutchan JA, Morgello S, Simpson DM, Franklin DR, Rosario D, Selph D, Letendre S, Grant I.  (2012). Mitochondrial DNA variation and HIV-associated sensory neuropathy in CHARTER. Journal of Neurovirology, 18(6), 511-520. PMID: 23073667  PMCID: PMC3587171  
Kamat A, Lyons JL, Misra V, Uno H, Morgello S, Singer EJ, Gabuzda D.  (2012). Monocyte activation markers in cerebrospinal fluid associated with impaired neurocognitive testing in advanced HIV infection. Basic and Translational Science, 60(3), 234-243. PMID: 22569268  PMCID: PMC3383928  
Patton DE, Woods SP, Franklin D, Cattie JE, Heaton RK, Collier AC, Marra C, Clifford D, Gelman B, McArthur J, Morgello S, Simpson D, McCutchan JA, Grant I.  (2012). Relationship of Medication Management Test-Revised (MMT-R) performance to neuropsychological functioning and antiretroviral adherence in adults with HIV. AIDS And Behavior, 16(8), 2286-2296. PMID: 22722882  PMCID: PMC3575112  
McCutchan JA, Marquie-Beck J, Fitzsimons C, Letendre SL, Ellis RJ, Heaton RK, Wolfson T, Rosario D, Alexander TJ, Marra C, Ances BM, Grant I, and the CHARTER Group.  (2012). Role of obesity, metabolic variables, and diabetes in HIV-associated neurocognitive disorder. Neurology, 78(7), 485-492. PMID: 22330412  PMCID: PMC3280051  
Croteau D, Letendre S, Best BM, Rossi SS, Ellis RJ, Clifford DB, Collier AC, Gelman BB, Marra CM, McArthur J, McCutchan JA, Morgello S, Simpson DM, Way L, Capparelli E, Grant I; and the CHARTER Group.  (2012). Therapeutic amprenavir concentrations in cerebrospinal fluid. Antimicrobial Agents and Chemotherapy, 56(4), 1985-89. PMID: 22290964  PMCID: PMC3318381  
Ellis RJ, Badiee J, Vaida F, Letendre S, Heaton RK, Clifford D, Collier AC, Gelman B, McArthur J, Morgello S, McCutchan JA, Grant I, and the CHARTER Group.  (2011). CD4 nadir is a predictor of HIV neurocognitive impairment in the era of combination antiretroviral therapy. AIDS (London, England), 25(14), 1747-1751. PMID: 21750419  PMCID: PMC3867631  
Jernigan TL, Archibald SL, Fennema-Notestine C, Taylor MJ, Theilmann RJ, Julaton MD, Notestine RJ, Wolfson T, Letendre SL, Ellis RJ, Heaton RK, Gamst AC, Franklin DR, Clifford DB, Collier AC, Gelman BB, Marra CM, McArthur JC, McCutchan JA, Morgello S, Simpson DM, Grant I, and the CHARTER Group.  (2011). Clinical factors related to brain structure in HIV: The CHARTER Study. Journal of NeuroVirology, 17, 248-257. PMID: 21544705  PMCID: PMC3702821  
Bharti AR, Letendre SL, Wolfson T, Clifford D, Collier AC, Gelman B, McArthur J, Marra C, McCutchan A, Morgello S, Simpson D, Ellis RJ, Grant I, for the CHARTER Group.  (2011). Clinical variables identify seronegative HCV co-infection in HIV-infected individuals. Journal of Clinical Virology, 52(4), 328-32. PMID: 21924674  PMCID: PMC3217127  
Best B, Koopmans P, Letendre S, Capparelli E, Rossi S, Clifford D, Collier A, Gelman B, Mbeo G, McCutchan J, Simpson D, Haubrich R, Ellis R, Grant I, and the CHARTER Group.  (2011). Efavirenz concentrations in cerebrospinal fluid exceed wild-type HIV IC50. Journal of Antimicrobial Chemotherapy, 66, 354-357. PMID: 21098541  PMCID: PMC3019085  
Lin K, Taylor MJ, Heaton RK, Franklin D, Jernigan TL, Fennema-Notestine C, McCutchan A, Atkinson JH, McArthur J, Morgello Simpson D, Collier A, Marra C, Gelman B, Clifford D, Grant I, and the CHARTER Group.  (2011). Effects of traumatic brain injury on cognitive functioning and cerebral metabolites in HIV infected individuals. Journal of Clinical and Experimental Neuropsychology, 33, 326-334. PMID: 21229435  PMCID: PMC3062232  
Moore DJ, Arce M, Moseley S, McCutchan JA, Marquie-Beck J, Franklin DR, Vaida F, Achim C, McArthur J, Morgello S, Simpson DM, Gelman BB, Collier AC, Marra CM, Clifford DB, Heaton RK, Grant I, the CHARTER Group and the HNRC Group.  (2011). Family history of dementia predicts worse neuropsychological functioning among HIV infected persons. Journal of Neuropsychiatry and Clinical Neurosciences, 23(3), 316-323. PMID: 21948893  PMCID: PMC3279193  
Heaton RK, Franklin DR, Ellis RJ, McCutchan JA, Letendre SL, Leblanc S, Corkran SH, Duarte NA, Clifford DB, Woods SP, Collier AC, Marra CM, Morgello S, Mindt M, Taylor MJ, Marcotte TD, Atkinson JH, Wolfson T, Gelman BB, McArthur JC, Simpson DM, Abramson I, Gamst A, Fennema-Notestine C, Jernigan TL, Wong J, Grant I, the CHARTER Group, and the HNRC Group.  (2011). HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: Differences in rates, nature, and predictors. Journal of NeuroVirology, 17(1), 3-16. PMID: 21174240  PMCID: PMC3032197  
Moore DJ, Letendre SL, Morris S, Umlauf A, Deutsch R, Smith DM, Little S, Rooney A, Franklin DR, Gouaux B, Leblanc S, Rosario D, Fennema-Notestine C, Heaton RK, Ellis RJ, Atkinson JH, Grant I, and the CHARTER Group.  (2011). Neurocognitive functioning in acute or early HIV infection. Journal of NeuroVirology, 17(1), 50-57. PMID: 21165782  PMCID: PMC3032208  
Byrd DA, Fellows RP, Morgello S, Franklin D, Heaton RK, Deutsch R, Atkinson JA, Clifford DB, Collier AC, Marra C, Gelman B, McCutchan JA, Duarte NA, Simpson D, McArthur J, Grant I, and the CHARTER Group.  (2011). Neurocognitive impact of substance use in HIV infection. Journal of Acquired Immune Deficiency Syndromes, 58(2), 154-162. PMID: 21725250  PMCID: PMC3183737  
Cysique LA, Franklin, D, Abramson I, Ellis RJ, Letendre S, Collier A, Clifford D, Gelman B, McArthur J, Morgello S, Simpson D, McCutchan JA, Grant I, Heaton RK, the CHARTER Group, and the HNRC Group.  (2011). Normative data and validation of a regression based summary score for assessing meaningful neuropsychological change. Journal of Clinical and Experimental Neuropsychology, 33, 505-522. PMID: 21391011  PMCID: PMC3151558  
Overton ET, Kauwe JSK, Paul R, Tashima K, Tate DF, Patel P, Carpenter CCJ, Patty D, Brooks JT, Clifford DB.  (2011). Performances on the CogState and Standard Neuropsychological Batteries among HIV patients without dementia. AIDS and Behavior, 15(8), 1902-1909. PMID: 21877204  PMCID: PMC3594991  
Robinson-Papp J, Morgello S, Vaida F, Fitzsimons C, Simpson D, Elliott K, Al-Lozi M, Gelman B, Clifford D, Marra C, McCutchan J, Atkinson J, Dworkin R, Grant I, Ellis R.  (2010). Association of self-reported painful symptoms with clinical and neurophysiologic signs in HIV-associated sensory neuropathy. Pain, 151, 732-736. PMID: 20851521  PMCID: PMC2972365  
Ellis R, Rosario D, Clifford D, McArthur J, Simpson D, Alexander T, Gelman B, Vaida F, Collier A, Marra C, Ances B, Atkinson JH, Dworkin R, Morgello S, Grant I, and the CHARTER Study Group.  (2010). Continued high prevalence and adverse clinical impact of human immunodeficiency virus–associated sensory neuropathy in the era of combination antiretroviral therapy: The CHARTER Study. Archives of Neurology, 67(5), 552-558. PMID: 20457954  PMCID: PMC3924778  
Heaton RK, Clifford DB, Franklin Jr DR, Woods SP, Ake C, Vaida F, Ellis RJ, Letendre SL, Marcotte TD, Atkinson JH, Rivera-Mindt M, Vigil OR, Taylor MJ, Collier AC, Marra CM, Gelman BB, McArthur JC, Morgello S, Simpson DM, McCutchan JA, Abramson I, Gamst A, Fennema-Notestine C, Jernigan TL, Wong J, Grant I, and the CHARTER Group.  (2010). HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study. Neurology, 75(23), 2087-2096. PMID: 21135382  PMCID: PMC2995535  
McArthur JC, Brew BJ.  (2010). HIV-associated neurocognitive disorders: is there a hidden epidemic? AIDS, 24(9), 1367-1370. PMID: 20559041  
Croteau D, Letendre S, Best BM, Ellis RJ, Breidinger S, Clifford D, Collier A, Gelman B, Marra C, Mbeo G, McCutchan A, Morgello S, Simpson D, Way L, Vaida F, Ueland S, Capparelli E, Grant I; and the CHARTER Group.  (2010). Total Raltegravir concentrations in cerebrospinal fluid exceed the 50% inhibitory concentration for wild-type HIV-1. Antimicrobial Agents and Chemotherapy, 54, 5156-5160. PMID: 20876368  PMCID: PMC2981289  
Best BM, Letendre SL, Brigid E, Clifford DB, Collier AC, Gelman BB, McArthur JC, McCutchan JA, Simpson DM, Ellis R, Capparelli EV, Grant I, and the CHARTER Group.  (2009). Low atazanavir concentrations in cerebrospinal fluid. AIDS, 23(1), 83-87. PMID: 19050389  PMCID: PMC2642983  
Gongvatana A, Schweinsburg BC, Taylor MJ, Theilmann RJ, Letendre SL, Alhassoon OM, Jacobus J, Woods SP, Jernigan TL, Ellis RJ, Frank LR, Grant I, and the CHARTER Group.  (2009). White matter tract injury and cognitive impairment in HIV-infected individuals. Journal of NeuroVirology, 15(2), 187-195. PMID: 19306228  PMCID: PMC3066173  
 Letendre S, McCutchan JA, Ellis RJ.  (2008). Highlights of the 15th Conference on Retroviruses and Opportunistic Infections. Neurologic complications of HIV disease and their treatment. Topics in HIV Medicine, 16(1), 15-22. PMID: 18441379  
Letendre S, Marquie-Beck J, Capparelli E, Best B, Clifford D, Collier AC, Gelman BB, McArthur JC, McCutchan JA, Morgello S, Simpson D, Grant I, Ellis RJ, and the CHARTER Group.  (2008). Validation of the CNS Penetration-Effectiveness rank for quantifying antiretroviral penetration into the central nervous system. Archives of Neurology, 65(1), 65-70. PMID: 18195140  PMCID: PMC2763187  
Letendre S, Marquie-Beck J, Ellis RJ, Woods SP, Best B, Clifford DB, Collier AC, Gelman BB, Marra C, McArthur JC, McCutchan JA, Morgello S, Simpson D, Alexander TJ, Durelle J, Heaton R, Grant I, and the CHARTER Group.  (2007). The role of cohort studies in drug development: clinical evidence of antiviral activity of serotonin reuptake inhibitors and HMG-CoA reductase inhibitors in the central nervous system. Journal of Neuroimmune Pharmacology, 2, 120-127. PMID: 18040835